Alan Marnett

 

arrow BenchFly (2009-present)

Position: Founder
Lab P.I./Group Leader:
       
Department:
       
Employer/University: BenchFly
Location: Cambridge MA
       
Focus: Biochemistry, Biology, Chemical Biology, Chemistry
Research Experience: Trying to make science better!
Collaborators:
Degree Earned:
 
 

arrow Postdoc - MIT: (2006-2009)

 
 

arrow Grad School - UCSF: (1999-2005)

 
 

arrow Tech - UCSD: (1998-1999)

 
 

arrow Tech - Vanderbilt: (1998-1998)

 
 

arrow Summer research - Vanderbilt: (1997-1997)

 
 

arrow Undergrad - Trinity: (1994-1997)

 

My BenchLife

When I'm not at the Bench, I'm: Playing golf, shooting videos or waiting for the summer finally to show up in Boston.
Who/What inspired me to become a Scientist: My father and the belief that through science, I had an opportunity to make a difference in the world.
My scientific idol is: Linus Pauling
In 10 years I hope to be: Overwhelmed by the efficiency and popularity of science!
Websites: http://www.alanmarnett.com
http://twitter.com/BenchFly
http://www.facebook.com/BenchFly
Alan Marnett

My Publications (11)

1: Substrate modulation of enzyme activity in the herpesvirus protease family.

Journal of Molecular Biology 373(4) 913-923 2007

Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS.

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2: One Functional Switch Mediates Reversible and Irreversible Inactivation of a Herpesvirus Protease.

Biochemistry 45(11) 3572-3579 2006

Nomura AM, Marnett AB, Shimba N, Dotsch V and Craik CS.

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3: Papa's got a brand new tag: Recent advances in identification of proteases and their natural substrates.

Trends in Biotechnology 23(2) 59-64 2005

Marnett AB and Craik CS.

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4: Induced structure: A transitional helix switch that regulates enzyme activity.

Nature Structural & Molecular Biology 12 1019-1020 2005

Nomura AM*, Marnett AB*, Shimba N, Dotsch V and Craik CS.

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5: Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.

Proceedings of the National Academy of Sciences 101(18) 6870-6875 2004

Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, and Craik CS.

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6: Herpesvirus protease inhibition by dimer disruption.

Journal of Virology 78(12) 6657-6665 2004

Shimba N, Nomura AM, Marnett AB and Craik CS.

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7: Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.

Proceedings of the National Academy of Sciences 97(2) 925-930 2000

Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, and Marnett LJ.

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8: Probing the active center gorge of acetylcholinesterase by fluorophores linked to substituted cysteines.

Journal of Biological Chemistry 275(29) 22401-22408 2000

Boyd AE, Marnett AB, Wong L, and Taylor P.

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9: Enantiocontrolled macrocycle formation by catalytic intramolecular cyclopropanation,

Journal of the American Chemical Society 122(24) 5718-5728 2000

Doyle MP, Hu W, Chapman B, Marnett AB, Peterson CS, Vitale JP, and Stanley SA.

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10: Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.

Journal of Medicinal Chemistry 43(15) 2860-2870 2000

Kalgutkar AS, Marnett AB, Crews BC, Remmel RP, and Marnett LJ.

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11: Macrocycle formation by catalytic intramolecular cyclopropanation. A new general methodology for the synthesis of macrolides

Journal of the American Chemical Society 119(38) 8826-8837 1997

Doyle MP, Peterson CS, Protopopova MN, Marnett AB, Parker DL, Ene DG, and Lynch V.

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