Comparing Capillary Cutters for LCMS
By Alan Marnett on March 26th, 2010
We know the little things matter in science. In fact, we spend much of our time troubleshooting laboratory techniques to find out exactly which little thing is ruining our experiments. It goes without saying that when working with an instrument as sensitive as a mass spectrometer, subtle differences in sample preparation or instrument tuning may dramatically affect the quality of the results. So when things go wrong, we’re not implying you should put every step under a microscope- but here’s what you may find if you do.
File this one under “Tips that may help you solve the mysterious variability in your experiments.” This video is a fantastic example of how two seemingly interchangeable techniques involving capillary cutters can actually yield significant differences. Little differences, but we’re heard about what the little things can do…